Serious adverse gastrointestinal reactions to non-steroidal anti-inflammatory drugs

Incidence of serious upper gastrointestinal bleeding in patients taking non-steroidal anti-inflammatory drugs in Japan.

Upper gastrointestinal bleeding is a major adverse event of non-steroidal anti-inflammatory drugs (NSAIDs), and co-administration of proton pump inhibitors and H2 receptor antagonists has been established as a means of preventing such an effect. However, the incidence of bleeding associated with NSAID-induced ulcers under conditions where such strong anti-acid agents are used for prevention has...

Non-steroidal anti-inflammatory drugs.

Adverse drug reactions in a primary care population prescribed non-steroidal anti-inflammatory drugs.

OBJECTIVE To determine how often patients with musculoskeletal (MSK) complaints prescribed a non-steroidal anti-inflammatory drug (NSAID) subsequently consult their general practitioner (GP) with a non-serious adverse drug reaction (ADR). DESIGN Cohort study. SETTING A healthcare database containing the electronic GP medical records of over 1.5 million patients throughout the Netherlands. ...

[Non-steroidal anti-inflammatory drugs (NSAIDs)].

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[Non-steroidal anti-inflammatory drugs (NSAID)].